Strategic plan for influenza flu

Key unanswered questions include the relative contribution of aerosols, droplets, and fomites as modes of transmission and the impact of environmental factors eg, temperature and humidity on each; the role of specific human subpopulations in epidemic or pandemic spread; and the level of herd immunity required to interrupt seasonal or pandemic influenza transmission.

View large Download slide Steps toward a universal influenza vaccine. The strategic plan builds upon a workshop NIAID convened in June that gathered scientists from academia, industry and government who developed criteria for defining a universal influenza vaccine, identified knowledge gaps, and delineated research strategies for addressing those gaps.

These plans aimed to stop, slow or otherwise limit the spread of a pandemic to the United States; limiting domestic spread, mitigating disease, suffering and death; and sustaining infrastructure and lessening the effects on the economy and society as a whole.

The strategic plan builds upon a workshop NIAID convened in June that gathered scientists from academia, industry and government who developed criteria for defining a universal influenza vaccine, identified knowledge gaps, and delineated research strategies for addressing those gaps.

Steps toward a universal influenza vaccine. The nation now faces new challenges — how to sustain the advances made, how to keep up with the changes in Strategic plan for influenza flu people live and work for example — and these challenges call for new approaches to better protect the nation against influenza pandemics.

Advances in influenza virology, immunology and vaccinology make the development of a universal influenza vaccine more feasible than a decade ago, according to the authors.

National Pandemic Influenza Plans

Develop and test models predicting the influence of preexisting immunity on virus evolution to anticipate the next emerging Strategic plan for influenza flu seasonal influenza virus strain.

Hopefully we are a lot closer than some folks thing. Identify host genetic and nongenetic factors eg, age and comorbidity that affect susceptibility to severe influenza outcomes.

Improve Understanding of How and When Exposure to Influenza Antigens Shapes the Host Response to Influenza Virus Infection and Vaccination Humans encounter numerous influenza virus strains and vaccinations throughout their lifetime, with immune responses determined by the genetics of the virus, as well as by intrinsic host factors, such as genetics, age, health, and immune status.

The cornerstone of both seasonal and pandemic influenza prevention and control is the development of vaccines against specific influenza strains that pose a potentially significant risk to the public. The lowest effectiveness occurs when vaccine strains are not well matched to circulating strains.

Identify immune markers associated with reduced disease severity. Define the mechanisms of broadly protective humoral immunity against influenza, including processes that affect immunodominance, based on antigen specificity, avidity, accessibility, or precursor frequency.

Characterize differences between immunity resulting from vaccination and from influenza virus infection. Steps toward a universal influenza vaccine. Figure 1 illustrates the steps that can guide ongoing research in this area. View large Download slide Criteria for a universal influenza vaccine.

NIAID will use this strategic plan as a foundation for future investments in influenza research. The cornerstone of both seasonal and pandemic influenza prevention and control is the development of vaccines against specific influenza strains that pose a potentially significant risk to the public.

Investment in basic research, including natural history and pathogenesis studies, will inform more-effective strategies for universal vaccine design. The knowledge gained from research area 2 will help to elucidate protective immune mechanisms triggered by both natural influenza virus infection and vaccination.

They describe the scientific goals that will be supported to advance influenza vaccine development.

NIAID Unveils Strategic Plan for Developing a Universal Influenza Vaccine

Determine the role of antineuraminidase NA antibodies in preventing virus budding, release, and transmission. It sounds like a tal Influenza A H3N2 viruses predominate season February 16, HealthDay —Most influenza viruses identified in the to season are influenza A, with A H3N2 viruses predominating, according to research published in the Feb.

Preparing for the next pandemic is an ongoing, iterative process. Developing a Better Flu Vaccine So what would we all want in a new and better flu vaccine. Building on discussions conducted during the workshop, the NIAID herein proposes a strategic plan to reinvigorate pursuit of a universal influenza vaccine.

The cornerstone of both seasonal and pandemic influenza prevention and control is the development of vaccines against specific influenza strains that pose a potentially significant risk to the public. The NIAID has made one of its highest priorities the development of a universal influenza vaccine that would provide long-lasting protection against multiple strains of the virus, including strains with the potential to cause a pandemic.

Seasonal influenza vaccines are made anew each year to best match the strains projected to circulate in the upcoming season. Explore how immunity develops and evolves over time in different age cohorts.

However, this approach has limitations and difficulties. Growing evidence suggests that tissue-resident innate and adaptive immune cells play a dominant role in protection and that development of tissue-specific immunity is influenced by the route or location of initial antigen exposure, vaccine formulation, and vaccine modality [ 1920 ].

Determine dynamics of viral spread across geographic regions. Those at high risk of complications from seasonal influenza include infants, elderly individuals, and people with medical comorbidities; these groups may respond differently to vaccination than healthy adults.

Centers for Disease Control Determine the role of bacterial or viral coinfections in the severity of influenza. Breadth or coverage of vaccine protection against influenza viruses, ranging from the least breadth ie, strain-specific protection through pan-group protection [ 11 ] to the greatest breadth ie, universal protection [ 12 ].

Feb 28,  · The strategic plan builds upon a workshop NIAID convened in June that gathered scientists from academia, industry and government who developed criteria for defining a universal influenza vaccine, identified knowledge gaps, and delineated research strategies for addressing those gaps.

This plan outlines activities in 3 main areas of influenza research: transmission, natural history, and pathogenesis studies using prospective cohorts; influenza immunity and correlates of immune protection; and strategies in rational vaccine design to elicit broad, protective immune responses.

The strategic plan builds upon a workshop NIAID convened in June that gathered scientists from academia, industry and government who developed criteria for defining a universal influenza vaccine, identified knowledge gaps, and delineated research strategies for addressing those gaps.

Interagency Strategic Plan for Avian Influenza Surveillance in Migratory Birds The United States Government is acutely aware of the threat the highly pathogenic H5N1. Strategic Pandemic Influenza Plan Version – April National Pandemic Flu Service Antiviral Stock Management.

This document outlines the strategic planning approach that Northumberland, Tyne and Wear NHS Trust (NTW) is adopting in preparing for a UK influenza pandemic. NIAID Unveils Strategic Plan for Developing a Universal Influenza Vaccine February 28, Writing in the Journal of Infectious Diseases, NIAID officials detail the institute’s new strategic plan for addressing the research areas essential to creating a safe and effective universal influenza vaccine.

Strategic plan for influenza flu
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